Fate of the thiomalate part after intramuscular administration of aurothiomalate in rheumatoid arthritis.

Fate of the thiomalate part after intramuscular administration of aurothiomalate in rheumatoid arthritis.

The excretory fate and plasma level of thiomalate were studied after intramuscular administration of auro-14C-thiomalate to 3 patients with rheumatoid arthritis. The gold and the thiomalate parts separated in vivo, and the free thiomalate was excreted in the urine, rapidly at first and then slowly. After one day about 60% of the 14C-label had been recovered in the urine. The plasma level also d...

Synovial fluid in antiquity.

7 Hall N D, Gillan A H. Effects of antirheumatic drugs on protein sulphydryl reactivity of human serum. J Pharm Pharmacol 1979; 31: 676-80. 8 Jellum E, Munthe E, Guldal G, Aaseth J. Fate of the gold and the thiomalate part after intramuscular administration of aurothiomalate to mice. Ann Rheum Dis 1980; 39: 155-8. 9 Munthe E, Guldal G, Jellum E. Increased intracellular glutathione during penici...

Intramuscular Administration of Steroids in Treatment of Rheumatoid Arthritis.

In a preliminary report (Zuckner, 1961) on intramuscular steroid therapy in patients with rheumatoid arthritis, results of approximately 100 injections of triamcinolone acetonide (hereafter referred to as TACTN)* and triamcinolone diacetate (or TDAC)t were described. The responses to this method of steroid administration were satisfactory in most cases, and compared favourably with those follow...

Free thiomalate levels in rheumatoid arthritis.

Free thiomalate levels in patients with rheumatoid arthritis treated with disodium aurothiomalate: relationship to clinical outcome of therapy.

Sixteen patients with seropositive rheumatoid arthritis were treated with 20 mg disodium aurothiomalate (Myocrisin) weekly for six months. Disease activity was assessed before and after treatment. Plasma profiles and urinary excretion of free thiomalate were measured in all patients after the initial injection and again at six months in the 12 patients remaining on therapy. No difference was fo...